An 86-year-old woman was airlifted to a Toronto trauma centre after a two-vehicle collision near Stayner.
The crash happened on Concession 12 at County Road 10 just after 2 p.m. on Wednesday.
The other driver, a 40-year-old man, was taken to a local hospital with minor injuries.
OPP traffic investigators are piecing together the details into what caused the crash.