A woman is in hospital with critical injuries after a crash on Highway 400.

The OPP closed the 400 at the Highway 11 split on Friday afternoon after a pickup truck hauling a trailer and van collided near Forbes Road.

A viewer video shows the pickup roll a number of times. Three people in the vehicle suffered minor injuries.

Provincial police say two people inside the van were transported to hospital, including a woman who has life threatening injuries.

The highway was closed for several hours while traffic investigators probed the scene.

Police and traffic investigators are still looking into the crash, but have not released a cause,  or said if charges will be laid.